Table 4.
Number of compounds mapping into individual cellular response categories of SOM
| F | J | M | N | P | Q | R | S | V | |
|---|---|---|---|---|---|---|---|---|---|
|
(a) |
29 (4.2%) |
44 (6.4%) |
129 (18.7%) |
102 (14.8%) |
92 (13.3%) |
83 (12.0%) |
25 (3.6%) |
140 (20.3%) |
46 (6.7%) |
|
(b) |
5 (2.6%) |
7 (3.6%) |
70 (36.1%) |
16 (8.2%) |
25 (12.9%) |
13 (6.7%) |
5 (2.6%) |
42 (21.6%) |
11 (5.7%) |
|
(c) |
3 (1.9%) |
5 (3.1%) |
62 (38.5%) |
16 (9.9%) |
19 (11.8%) |
9 (5.6%) |
3 (1.9%) |
35 (21.7%) |
9 (5.6%) |
|
(d) |
2 (7.4%) |
1 (3.7%) |
6 (22.2%) |
0 (0%) |
5 (18.5%) |
4 (14.8%) |
1 (3.7%) |
7 (25.9%) |
1 (3.7%) |
|
p-ab |
0.3988 |
0.1653 |
<0.0001 |
0.0169 |
1.0000 |
0.0365 |
0.6537 |
0.6882 |
0.7412 |
|
p-ac |
0.2469 |
0.1326 |
<0.0001 |
0.1283 |
0.6970 |
0.0163 |
0.3325 |
0.6663 |
0.7235 |
| p-ad | Numbers too small for statistical evaluation | ||||||||
(a) all 793 evaluable compounds (b) 136 CSC inhibitory compounds; (c) 99 CSC and OVCAR-3 co-inhibitory compounds; (d) 32 CSC-specific inhibitory compounds. P-values: Fisher’s exact test for the significance of differences between proportions of compounds in a given cellular response category in 793 compound set (A) and compound subset B (p-AB), C (p-AC), or D (p-AD). [mitosis (M), membrane function (N), nucleic acid metabolism (S), metabolic stress and cell survival (Q), kinases/phosphatases and oxidative stress (P) and 4 unexplored regions (RFJV)].