Table 2. Effects of calcium on the antifungal activity versus mutant C. albicans strains.
Antifungal MIC80 (µg/ml)a | Strains | |||||||
cnaΔ/Δ::CNA | rta2Δ/Δ cnaΔ/Δ::CNA | cnaΔ/Δ rta2Δ/Δ::RTA2 | crz1Δ/ Δ::CRZ1 | rta2Δ/Δ crz1Δ/ Δ::CRZ1 | crz1Δ/Δ rta2Δ/ Δ::RTA2 | rta2Δ/Δ::RTA2 | ||
Fluconazole | – | 0.5 | 0.125 | 0.06 | 0.5 | 0.125 | 0.125 | 0.5 |
+1mM CaCl2 | 16 | 0.25 | 0.125 | 16 | 0.25 | 0.25 | 64 | |
Caspofungin | – | 0.3 | 0.6 | 0.6 | 0.3 | 0.3 | 0.15 | 0.3 |
+1mM CaCl2 | 0.3 | 0.6 | 0.6 | 0.6 | 0.6 | 0.3 | 0.3 |
MIC80s were determined after 48 h incubation and all experiments were performed in triplicate.