Table 1. Physiological Variables.
Young animals | Aged animals | |||||
Saline | DHA | NPD1 | Saline | DHA | NPD1 | |
(n = 8) | (n = 7) | (n = 8) | (n = 10) | (n = 9) | (n = 8) | |
Before MCAo (15 min) | ||||||
Rectal temperature (°C) | 36.6±0.1 | 36.7±0.1 | 36.7±0.1 | 37.0±0.0 | 36.8±0.2 | 37.1±0.1 |
Cranial temperature (°C) | 36.4±0.1 | 36.8±0.1 | 36.5±0.1 | 37.0±0.0 | 36.6±0.2 | 37.1±0.2 |
pH | 7.42±0.01 | 7.42±0.01 | 7.43±0.01 | 7.44±0.02 | 7.44±0.01 | 7.46±0.01 |
PO2, mm Hg | 123±8 | 127±10 | 119±7 | 100±7 | 109±9 | 108±7 |
PCO2, mm Hg | 39±1 | 39±1 | 39±01 | 38±1 | 39±1 | 38±01 |
Plasma glucose, mg/dL | 135±5 | 139±10 | 157±10 | 239±17 | 246±32 | 211±10 |
Body weight (g) | 302±7 | 294±14 | 302±8 | 578±13 | 575±9 | 542±8 |
During MCAo (15 min) | ||||||
Rectal temperature (°C) | 37.3±0.2 | 36.5±0.02 | 36.6±0.1 | 38.0±0.0 | 37.7±0.2 | 37.4±0.2 |
Cranial temperature (°C) | 36.5±0.1 | 36.7±0.1 | 36.4±0.1 | 37.0±0.0 | 37.1±0.1 | 36.9±0.1 |
pH | 7.42±0.01 | 7.40±0.01 | 7.43±0.01 | 7.44±0.01 | 7.44±0.01 | 7.46±0.01 |
PO2, mm Hg | 106±3 | 106±4 | 107±4 | 90±5 | 93±2 | 99±4 |
PCO2, mm Hg | 40±1 | 40±1 | 39±1 | 39±1 | 40±1 | 39±1 |
Plasma glucose, mg/dL | 133±7 | 135±6 | 142±9 | 207±9 | 231±29 | 169±7 |
After treatment (15 min) | ||||||
Rectal temperature (°C) | 36.9±0.2 | 36.4±0.3 | 36.8±0.2 | 37.0±0.0 | 36.4±0.1 | 37.0±0.2 |
Cranial temperature (°C) | 36.4±0.1 | 36.1±0.2 | 36.2±0.2 | 37.0±0.0 | 36.9±0.2 | 36.8±0.2 |
After treatment (24 h) | ||||||
Rectal temperature (°C) | 37.8±0.2 | 38.4±0.4 | 37.4±0.2 | 37.0±0.0 | 37.4±0.2 | 37.8±0.2 |
Body weight (g) | 272±9 | 269±11 | 280±7 | 544±11 | 553±7 | 521±9 |
After treatment (48 h) | ||||||
Rectal temperature (°C) | 37.6±0.3 | 37.7±0.4 | 37.1±0.1 | 37.0±0.1 | 37.6±0.3 | 37.9±0.1 |
Body weight (g) | 269±10 | 261±9 | 284±7 | 510±13 | 537±6 | 519±11 |
After treatment (72 h) | ||||||
Rectal temperature (°C) | 37.5±0.4 | 37.5±0.3 | 37.1±0.1 | 37.0±0.1 | 37.6±0.3 | 37.7±0.1 |
Body weight (g) | 269±14 | 263±13 | 293±6 | 514±13 | 528±7 | 508±11 |
After treatment (7 days) | ||||||
Rectal temperature (°C) | 37.6±0.7 | 37.6±0.3 | 37.1±0.2 | 37.0±0.0 | 37.9±0.2 | 37.5±0.3 |
Body weight (g) | 284±25 | 301±11 | 322±7 | 510±16 | 531±7 | 520±8 |
Values are mean ± SEM.
MCAo, middle cerebral artery occlusion.