Table 2.
Comparison of Biomarkers by Treatment Group
| 17-OHPC | Placebo | P value | |||
|---|---|---|---|---|---|
| N | Median (IQR) | N | Median (IQR) | ||
|
| |||||
| CRH | |||||
|
| |||||
| -at 1st blood draw (pg/ml) | 80 | 382 (299–493) | 96 | 373 (291–503) | 0.64 |
| -at 2nd blood draw (pg/ml) | 59 | 789 (624–1285) | 68 | 1018 (740–1521) | 0.09 |
| -change rate (pg/ml/wk) | 59 | 67 (40–122) | 68 | 93 (49–157) | 0.17 |
|
| |||||
| CRP | |||||
|
| |||||
| -at 1st blood draw (pg/ml) | 95 | 10420 (5729–19315) | 112 | 7858 (4152–13995) | 0.005 |
| -at 2nd blood draw (pg/ml) | 68 | 9266 (5255–15312) | 86 | 7597 (3711–15583) | 0.33 |
| -change rate (pg/ml/wk) | 68 | −218 (−1551 – 475) | 86 | 12 (−397 – 648) | 0.02 |
|
| |||||
| Progesterone | |||||
|
| |||||
| - at 1st blood draw (ng/ml) | 96 | 120.3 (96.2–148.2) | 115 | 112.5 (90.0– 133.9) | 0.09 |
| -at 2nd blood draw (ng/ml) | 70 | 195.1 (165.1–249.3) | 88 | 174.9 (144.5–230.8) | 0.14 |
| -change rate (ng/ml/wk) | 70 | 13.0 (7.8–17.7) | 88 | 10.9 (6.0–15.2) | 0.14 |
|
| |||||
| 17-hydroxyprogesterone | |||||
|
| |||||
| - at 1st blood draw (ng/ml) | 96 | 4.3 (3.0–5.7) | 113 | 4.2 (3.3–5.8) | 0.64 |
| - at 2nd blood draw (ng/ml) | 70 | 5.9 (4.5–8.2) | 86 | 5.7 (3.8–7.6) | 0.43 |
| - rate (ng/ml/wk) | 70 | 0.3 (0.1–0.5) | 86 | 0.2 (0.0– 0.4) | 0.25 |
| 17-hydroxyprogesterone caproate | |||||
|
| |||||
| - at 1st blood draw (ng/ml) | 97 | 10.4 (7.0–13.9) | ND | ||
|
| |||||
| - at 2nd blood draw (ng/ml) | 71 | 12.0 (8.7–16.3) | ND | ||
|
| |||||
| - rate (ng/ml/wk) | 71 | 0.2 (0.0–0.9) | NA | ||
Change rate was estimated as value at epoch 2 – value at epoch 1 divided by weeks elapsed
CRP: c- reactive protein; CRH: corticotropin releasing hormone; IQR: Interquartile range; ND –not detectable; NA – not applicable