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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Chem Biol Drug Des. 2012 Oct 9;80(6):810–820. doi: 10.1111/cbdd.12040

Figure 5.

Figure 5

Neuron and astrocyte specific activation of Nrf2-ARE after 822 treatment. Panel A and B, hPAP histochemical staining of vehicle (A) or 20μM 822 (B) in neuronally enriched culture. NQO1 histochemical staining of vehicle (C) or 20μM 822 (D) in neuronally enriched culture. hPAP activity was quantified in neuron cultures at 20μM (E) and astrocytes at 50μM (G), with significant activation of hPAP activity and no corresponding toxicity (F, H). Values are the mean ± SEM (n=3). *Significantly different than the corresponding vehicle-treated value (p<0.05).