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. Author manuscript; available in PMC: 2013 Sep 28.
Published in final edited form as: Oncogene. 2012 May 21;32(13):1616–1625. doi: 10.1038/onc.2012.193

Figure 2.

Figure 2

Gene and gene sets regulated by HOTAIR in Panc1 cells and comparisons with MDAMB-231 breast cancer cells. (A) HOTAIR knockdown and GSEA analysis of GO terms showed that HOTAIR knockdown enriched expression of genes involved in cell cycle progression. (B) Venn diagram and heat map of genes regulated by HOTAIR in Panc 1 and MDA-MB-231 cells by HOTAIR knockdown and overexpression, respectively, and a summary of coordinate and independent regulation of genes by HOTAIR knockdown in Panc1 and HOTAIR overexpression (20) in MDA-MB-231 cells. Effects of siHOTAIR in Panc1 cells on genes suppressed (C) or induced (D) by HOTAIR overexpression in MDAMB-231 cells (20). Gene expression was determined by real time PCR and results are expressed as mean ± SE for 3 replicate determinations and significant (p < 0.05) is indicated (*). siHOTAIR was used in the knockdown studies.