Table 4.
Comparison of long- and short-MDI for PDD patients
| PDD- Short MDI N=50 |
PDD- Long MDI N=42 |
P-value | |
|---|---|---|---|
| Number of Patients (%M) | 44/50 (88.0%) | 28/42 (66.7%) | 0.0131 |
|
Age of Motor Onset (years) Median (IQR) |
69.50 (64.75, 75.25) | 58.50 (50.00, 63.00) | <0.0012 |
|
Age of Dementia Onset (years) Median (IQR) |
74.00 (71.25, 80.00) | 74.50 (68.75, 77.75) | 0.5402 |
|
Age of Death (years) Median (IQR) |
79.00 (73.00, 83.25) | 78.00 (74.00, 81.25) | 0.7182 |
|
Disease Duration (years) Median (IQR) |
9.00 (8.00, 11.25) | 19.50 (15.75, 23.00) | <0.0012 |
|
Motor-Dementia Interval (years) Median (IQR) |
5.00 (4.00, 8.00) | 14.00 (12.00, 19.00) | NA |
|
Dementia-Death Interval (years) Median (IQR) |
4.00 (2.00, 6.00) | 3.50 (1.00, 6.00) | 0.8892 |
|
Brain Weight (grams) Median (IQR) |
1308.00 (1220.0, 1486.0)* | 1285.5 (1185.25, 1400.0) | 0.1253 |
| APOE4 N (% carriers) | 23/48 (47.9%) | 17/41 (41.5%) | 0.5421 |
| H1/H1 Haplotype (% carriers) | 25/37 (67.6%) | 26/40 (65.0%) | 0.6391 |
|
Braak Stage N (% cases) 0 I–II III–IV V–VI |
1/46 (2.2%) 15/46 (32.6%) 15/46 (32.6%) 15/46 (32.6%) |
6/40 (15.0%) 20/40 (50.0%) 8/40 (20.0%) 6/40 (15.0%) |
0.0101 |
|
CERAD Stage N (% cases) 0 A B C |
14/46 (30.4%) 3/46 (6.5%) 11/46 (23.9%) 18/46 (39.1%) |
23/42 (54.8%) 2/42 (4.8%) 7/42 (16.7%) 10/42 (23.8%) |
0.1211 |
| AD diagnosis N (% cases) | 22/46 (47.8%) | 11/40 (27.5%) | 0.0271 |
|
LB/LN Stage N (% cases) Brainstem Limbic Neocortical |
0/48 (0.0%) 4/48 (8.3%) 44/48 (91.7%) |
0/39 (0.0%) 11/39 (28.2%) 28/39 (74.4%) |
0.0191 |
|
Global Cortical NFT N Median (IQR) |
42 0.67 (0.33, 1.2) |
38 0.43 (0.13, 0.67) |
0.0032 |
|
Global Cortical SP N Median (IQR) |
45 1.6 (0.03, 2.50) |
40 0.33 (0.00, 2.10) |
0.1122 |
|
Global Cortical LB/LN N Median (IQR) |
44 1.87 (1.22, 2.50) |
38 1.20 (1.00, 2.13) |
0.0282 |
1
Chi-Square,
2
Mann Whitney-U,
3
Independent T-test.
*
Missing data from 1 case.