Fig. 5.

Survival rate in CD1 nude mice-bearing intracranial U87 MG cells. Kaplan-Meier survival of CD1 nude mice treated with 0.3 M NaCl 50 ml/day (n = 13), OxAc 2.14 mg/kg/day/hGOT 2.14 mg/kg on the first day followed by a maintenance dose of 0. 214 mg hGOT/kg/day (n = 13), TMZ 5 mg/kg for 4 days (n = 13) and a combined TMZ/ OxAc/hGOT treatment with the same doses as the rest groups (n = 13). Animals were monitored up to 115 days after the tumor cell implantation. P-Values obtained using a Long-rank test show P < 0.0001