Table 2.
Annualized atrophy rate differences for smokers and nonsmokers in statistically significant regions of interest
| Region | Rate Difference (mm3/year) | Standard error | Corrected p-value |
|---|---|---|---|
| BRS/Anterior Brain Regions | |||
| Rostral Middle frontal gyrus | -201.73 | 70.24 | 0.02 |
| Pars triangularis | -51.54 | 17.38 | 0.02 |
| Medial Orbitofrontal Cortex | -56.22 | 22.05 | 0.03 |
| Pars Orbitalis | -28.49 | 10.77 | 0.03 |
| Lateral Orbitofrontal Cortex | -66.30 | 29.08 | 0.04 |
| Frontal Pole | -17.24 | 6.24 | 0.04 |
| AD/Posterior Brain Regions | |||
| Isthmus of Cingulate gyrus | -28.76 | 9.94 | 0.02 |
| Inferior parietal lobule | -193.24 | 64.87 | 0.02 |
| Posterior Cingulate Gyrus | -42.55 | 15.75 | 0.03 |
| Precuneus | -108.96 | 40.79 | 0.03 |
| Lingual Gyrus | -61.00 | 24.61 | 0.03 |
| Parahippocampal Gyrus | -25.00 | 10.95 | 0.04 |
| Fusiform Gyrus | -91.62 | 39.54 | 0.04 |
| Middle Temporal Gyrus | -120.61 | 46.91 | 0.04 |
Note. Rate difference for each region indicates the amount of tissue volume lost per year in smokers relative to non-smokers. AD: Alzheimer Disease; BRS: Brain Reward System.