Table 2.

Effects of Clinically Effective Medications on Animal Models of Alcohol Addiction

	Animal Model	Naltrexone	Acamprosate	Topiramate
Acute Reinforcing Effects of Alcohol	Alcohol self-administration	↓	No effect	↓
	Conditioned place preference	↓	↓	No effect
	Alcohol deprivation effect	↓	↓	↓
	Increased alcohol self- administration (dependent animals)	↓	↓	↓
Withdrawal/Negative Affect	Anxiety-like responses	No effect	↓	↓
	Conditioned place aversion	No effect*	Not reported	Not reported
Relapse to Heavy Drinking	Stress-induced reinstatement	No effect	Not reported	↓†
	Alcohol-induced reinstatement	↓	Not reported	Not reported
	Cue-induced reinstatement	↓	↓	Not reported

Data based on Egli, 2005 and Koob et al., 2009.

^*Naloxone had no effect on expression of conditioned place aversion, but enhanced acquisition.

^†Topiramate reduced stress enhanced ethanol drinking in C57 mice.