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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Neurotoxicology. 2012 Sep 14;33(5):1381–1389. doi: 10.1016/j.neuro.2012.09.003

Figure 3. Voltage dependence of slow inactivation of Nav1.4 and Val787 mutated sodium channels.

Figure 3

Oocytes were clamped at a holding potential (Vh) of either −120 mV (Nav1.4, Nav1.4/V787A, Nav1.4/V787C channels) or −140 mV (Nav1.4/V787K channels) and stimulated with either a 100-s (Nav1.4, Nav1.4/V787A, Nav1.4/V787C) or 10-s (Nav1.4/V787K) conditioning pulse (Vp) to potentials ranging from Vh to 0 mV followed by a 50-ms hyperpolarization to Vh and a test pulse to either −10 mV (Nav1.4, Nav1.4/V787C, Nav1.4/V787K) or 0 mV (Nav1.4/V787A); peak currents were normalized to the maximal current measured during the inactivation protocol for that oocyte; values are means ± S.E. of 7 (Nav1.4, 4 (Nav1.4/V787A), 5 (Nav1.4/V787C), or 6 (Nav1.4/V787K) separate experiments with different oocytes; curves were fitted to the mean values using the Boltzmann equation.