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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Neurotoxicology. 2012 Sep 14;33(5):1381–1389. doi: 10.1016/j.neuro.2012.09.003

Figure 5. Effect of hyperpolarization on Nav1.4/V787K currents and their inhibition by indoxacarb.

Figure 5

Oocytes were clamped at a holding potential (Vh) of −140 mV for 5 min followed by 5 min at a Vh of −150 mV while stimulated at a rate of 0.05 Hz with a test pulse (20 ms) to −10 mV; sodium currents were normalized to the maximum current recorded in the same oocyte at − 140 mV prior to indoxacarb perfusion; values are means ± S.E. of 7 separate experiments in different oocytes; curves were fitted to the mean values using a single-exponential decay equation.