Table 1.

Voltage-dependent gating parameters for wildtype and Val787 mutated Na_v1.4 sodium channels ^a.

	Activation			Fast inactivation			Slow inactivation
Channel	V1/2 (mV)	k	[n]	V1/2 (mV)	k	[n]	V1/2 (mV)	k	[n]
Nav1.4	−25.8 ± 0.4	5.0 ± 0.4	[15]	−52.2 ± 0.3	5.5 ± 0.2	[11]	−45.8 ± 0.8	9.4 ± 0.7	[7]
Nav1.4/V787A	−18.8 ± 0.6*	7.0 ± 0.5*	[9]	−59.2 ± 0.6*	5.9 ± 0.5	[9]	−39.8 ± 1.8	10.8 ± 1.6	[4]
Nav1.4/V787C	−18.3 ± 0.6*	6.6 ± 0.5†	[7]	−53.8 ± 0.4	5.6 ± 0.4	[5]	−41.4 ± 3.4	10.4 ± 2.9	[5]
Nav1.4/V787K	−23.9 ± 0.7	6.6 ± 0.6§	[11]	−60.1 ± 0.5*	5.1 ± 0.5	[4]	−92.6 ± 1.2*	11.4 ± 1.0	[6]

^aValues calculated from fits of mean data (Fig. 2, Fig. 3) to the Boltzmann equation; V_1/2, midpoint potential (mV) for voltage-dependent activation or inactivation; k, slope factor.

^*= P < 0.001

^§= P < 0.01

^†= P < 0.05 compared with wildtype.