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. 2012 Oct 24;122(11):4218–4230. doi: 10.1172/JCI59176

Figure 5. Cx40 deficiency attenuates chronic hypoxic pulmonary hypertension.

Figure 5

Group data showing (A) right ventricular systolic pressure (RVSP) and (B) right ventricular weight relative to septal and left ventricular weight (Fulton index) in Cx40+/+ and Cx40–/– mice housed in either normoxia (21% O2) or hypoxia (10% O2) for 5 weeks. (C) Representative images of H&E-stained lung sections showing pulmonary arterioles (denoted by 4 arrowheads each). Scale bar: 50 μm. (D) Group data (n = 8 mice each) showing degree of vascular muscularization in pulmonary arterioles 20–50 μm in diameter, expressed as proportion of non-, partially, or fully muscularized vessels, in lungs from normoxic and hypoxic Cx40+/+ and Cx40–/– mice. *P < 0.05 vs. normoxia; #P < 0.05 vs. Cx40+/+.