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. 2012 Oct 8;122(11):4025–4036. doi: 10.1172/JCI59348

Figure 6. Effect of MMP9 and PN1 on orthotopic prostate tumor growth.

Figure 6

(A) MRI image (left panel) of a prostate tumor in a WT mouse following intraprostate injection with the metastatic mouse carcinoma line TrampC2 at 12 weeks. Contouring (middle panel): bladder (blue); tumor (green); prostate (red). 3D model representation (right panel). (B) Tumor volume from MRI in indicated mice. Mann-Whitney U test. (n = 5). (C) Tumor volume in WT and pn1–/– mouse tumors using MRI. Mann-Whitney U test (n = 5). (D) Immunoblot detection of PN1, SHH, and GLI1 tumors grown in WT or pn1–/– mice. (E) Volumes from intraprostate TrampC2 tumors stably expressing SHH in pn1–/–, mmp9–/–, and WT mice (n = 6). *P ≤ 0.05.