Skip to main content
. 2012 Oct 8;122(11):4025–4036. doi: 10.1172/JCI59348

Figure 8. Genetic alteration of Hh proteins in human prostate cancer.

Figure 8

(A) Proportion of patients with no genetic alteration or 1 or more CNAs in Hh genes. (B) Genetic analysis of cohort (n = 126) shows that n = 35 patients presented with 2 or more Hh gene CNAs; the latter tumors had increased percentages of genome alteration (PGA; P < 0.0001). Horizontal bars show median values of the 2 groups of patients. (C) Kaplan-Meier plot and univariate analysis showing increased biochemical relapse in patients with 2 or more CNAs in Hh gene set (HR = 3.27; P < 0.00048).