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. 2012 Oct 8;122(11):3955–3959. doi: 10.1172/JCI63113

Figure 3. PGRN-deficient microglia exhibit a hyperactivated inflammatory response.

Figure 3

(A) Increased inflammatory cytokine mRNA levels in LPS/IFN-γ–treated Grn–/– microglia, compared with Grn+/+ controls, that was rescued by lentiviral infection with murine PGRN (MuGrn). *P < 0.05 compared with PBS; †P < 0.05 compared with Grn–/– LPS/IFN-γ. (B) Representative time plots revealing increased secretion of inflammatory cytokines by LPS/IFN-γ–treated Grn–/– microglia compared with similarly treated Grn+/+ cultures.