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. 2012 Oct 1;122(11):4118–4129. doi: 10.1172/JCI63606

Figure 5. TLR7 ligation exacerbates pancreatic fibroinflammation, while TLR7 inhibition is protective.

Figure 5

Chronic pancreatitis was induced in 6-week-old WT or Tlr7–/– mice using caerulein. Selected cohorts of WT mice were additionally treated with ssRNA40. (A) Pancreata were stained using H&E, trichrome, or mAbs directed against CD45 and α-SMA. Original magnification, ×10 (H&E); ×20 (CD45); ×40 (trichrome and a-SMA). Scale bars: 300 μm (H&E); 150 μm (CD45); 75 μm (trichrome and a-SMA). (B) Surface area occupied by acinar units and (C) fibrotic surface area were determined using a computerized grid. (D) CD45+ leukocytic infiltrate was quantified by examining 10 HPFs per pancreas. n = 5 per group. ***P < 0.001.