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. 2012 Oct 1;122(11):3919–3930. doi: 10.1172/JCI63888

Figure 1. An MFBD promotes sphingolipid-dependent cardiac hypertrophy.

Figure 1

Mice fed an MFBD for 18 weeks (A) did not experience greater obesity than mice on a traditional LBD, but they displayed (B) marked cardiac hypertrophy and (C) increased cardiomyocyte cross-sectional area. Myriocin treatment attenuated this hypertrophy without affecting weight gain. Black bars, control plus DMSO; light gray bars, milk fat plus DMSO; dark gray bars, milk fat plus myriocin; hatched bars, lard plus DMSO. All results are given as mean ± SEM. *P < 0.05 vs. control.