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. 2012 Oct 15;122(11):3960–3964. doi: 10.1172/JCI64583

Figure 3. Genetic relief of ER stress selectively in the SFO prevents Ang II–induced HTN and ROS production.

Figure 3

An adenovirus encoding the ER molecular chaperone GRP78 was targeted to SFO 1 week prior to the start of systemic Ang II infusions. (A) Mean AP measured by radiotelemetry during Ang II infusions in conscious mice with SFO-targeted AdGRP78 or control vector AdLacZ (n = 4–5). (B) Schematic of a coronal brain section containing the SFO (lower left) and representative DHE fluorescence images of SFO from untreated mice or from mice with SFO-targeted injections of AdLacZ or AdGRP78. Summary data are shown on the bottom right (n = 4). Scale bar: 50 μm. *P < 0.05 versus day 0 or untreated; †P < 0.05 versus AdLacZ.