Figure 4.

Complementation Analysis in VI-3 and Control Fibroblasts

After transient transfection with a construct encoding wild-type RMND1, mutant cells showed increased biochemical activities of mitochondrial respiratory-chain enzymes normalized to citrate synthase (CS) (A) and an increase in the steady-state level of mitochondrial OXPHOS subunits (B and C). Values are represented as the mean ± standard deviation, reflect the results of at least three different transfection experiments, and are expressed as percentages of the untransfected control. The asterisks (^∗) indicate a Student’s t test p < 0.05.