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Multiple origins of carcinoma associated fibroblasts. This drawing depicts the proposed origins of CAFs including the bone marrow (HSC and MSC), epithelial and tumor cells via EMT, endothelial cells via EndMT, resident fibroblasts and adipocytes. HSC= hematopoietic stem cell; MSC= mesenchymal stem cell; EMT= epithelial-mesenchymal transition; EndMT= endothelial-mesenchymal transition.
