Table 2.

Loci with Strong Evidence of Association with Serum Albumin and Total Protein after Transethnic MANTRA Analysis of European-Ancestry and Japanese GWASs

Lead SNP	Chr	Position (Build 36)	Alleles		European Ancestry GWAS Meta-analysis					Japanese GWAS					MANTRA Transethnic Meta-analysis		Locus
			Effect	Other	EAF	Beta	SE	p Value	Sample Size	EAF	Beta	SE	p Value	Sample Size	log10BF Association	log10BF Heterogeneity
Serum Albumin Established Loci
rs1260326	2	27,584,444	T	C	0.41	0.0124	0.0016	2.9 × 10−14	53,189	0.56	0.0270	0.0050	2.2 × 10−8	9,380	17.01	0.28	GCKR-FNDC4
rs4806073	19	40,247,030	C	T	0.93	0.0257	0.0033	3.3 × 10−15	53,187	0.92	0.0380	0.0090	1.3 × 10−5	9,380	15.81	−0.08	HPN-SCN1B
rs11078597	17	1,565,113	C	T	0.18	0.0205	0.0029	6.8 × 10−13	38,231	0.18	0.0200	0.0060	1.8 × 10−3	9,380	12.51	0.20	SERPINF2-WDR81
rs694419	18	58,277,092	T	C	0.52	0.0093	0.0016	1.2 × 10−8	53,189	0.05	0.0180	0.0110	9.2 × 10−2	9,380	7.05	−0.11	TNFRSF11A-ZCCHC2
rs2280401	19	54,691,821	A	G	0.17	0.0121	0.0024	7.6 × 10−7	53,189	0.16	0.0240	0.0070	3.1 × 10−4	9,380	6.96	0.13	RPS11-FCGRT
rs16948098	15	42,006,899	A	C	0.06	0.0229	0.0041	1.9 × 10−8	53,189	0.00					4.79		FRMD5-WDR76
Serum Albumin Additional Potential Loci
rs2293579	11	47,397,334	A	G	0.40	0.0093	0.0017	8.0 × 10−8	53,189	0.26	0.0030	0.0050	5.7 × 10−1	9,380	5.61	−0.05	PSMC3
rs12914385	15	76,685,778	C	T	0.61	0.0064	0.0016	8.7 × 10−5	53,189	0.70	0.0200	0.0050	1.3 × 10−4	9,380	5.07	0.12	CHRNA3- CHRNA5
Total Protein Established Loci
rs4561508	17	16,789,475	T	C	0.11	0.0360	0.0060	1.3 × 10−9	25,534	0.37	0.0470	0.0700	2.0 × 10−11	10,168	16.25	−0.00	TNFRSF13B
rs204999	6	32,217,957	A	G	0.74	0.0250	0.0040	3.4 × 10−9	25,537	0.94	0.0420	0.0130	1.7 × 10−3	10,168	9.01	0.10	6q21.3
rs2280401	19	54,691,821	A	G	0.16	0.0120	0.0050	1.5 × 10−2	25,537	0.16	0.0500	0.0090	6.5 × 10−8	10,168	5.19	0.96	RPS11-FCGRT
Total Protein Additional Potential Loci
rs3777200	5	95,260,547	T	C	0.27	0.0180	0.0040	1.9 × 10−5	25,524	0.30	0.0290	0.0070	1.1 × 10−4	10,168	6.57	−0.14	ELL2
rs1260326	2	27,584,444	T	C	0.44	0.0150	0.0040	1.1 × 10−4	25,537	0.56	0.0310	0.0070	3.7 × 10−6	10,168	5.93	−0.02	GCKR-FNDC4
rs2675609	10	63,306,537	T	C	0.39	0.0090	0.0040	1.4 × 10−2	25,537	0.43	−0.0360	0.0070	1.7 × 10−6	10,168	5.81	6.79	ARID5B
rs10097731	8	82,190,227	T	G	0.15	0.0230	0.0050	1.1 × 10−5	25,537	0.17	0.0310	0.0090	5.9 × 10−4	10,168	5.67	0.19	PAG1

Strong evidence is defined as log₁₀ BF > 5. The following abbreviations are used: Chr, chromosome; GWAS, genome-wide association study; MANTRA, meta-analysis of transethnic association studies; EAF, effect allele frequency; and BF, Bayes factor.