Table 1. High-confidence PDZ domain-encoding genes in border cell migration identified by RNAi knockdown.
| Gene | Putative Vertebrate Homologa | Other Domains Presentb | No. of Hits / Total Linesc | Known Role in Cell Migrationd |
|---|---|---|---|---|
| bazooka | PARD3 (PAR3) | Oligomerization domain | 2 / 2 | Pinheiro and Montell (2004)e |
| Nakayama et al. (2008)f | ||||
| big bang | PDZD2 | None | 2 / 3 | — |
| CASK ortholog | CASK | Guanylate kinase domain | 2 / 3 | — |
| L27 domain | ||||
| Protein kinase, catalytic domain, inactive | ||||
| SH3 domain | ||||
| CG5921 | Harmonin / USH1C | None | 2 / 2 | — |
| CG6498 | MAST2 | Domain of unknown function | 3 / 3 | — |
| Protein kinase, catalytic domain | ||||
| CG6509 | DLG5 | Guanylate kinase domain | 2 / 3 | Smolen et al. (2010)f |
| Src homology 3 domain | ||||
| Gef26 | RAPGEF2 / PDZ-GEF1 | Cyclic nucleotide-binding domain | 3 / 3 | Huelsmann et al. (2006)e |
| Guanine-nucleotide dissociation stimulator (RasGEF) | ||||
| Ras association domain | ||||
| Ras-like guanine nucleotide exchange factor, N-terminal | ||||
| Lap1 | LRRC7 / ERBB2IP | Leucine-rich repeats | 2 / 2 | — |
| LIMK1 | LIMK1 | LIM zinc-binding domain | 2 / 3 | Zhang et al. (2011)e |
| Protein kinase, catalytic domain | Nishita et al. (2005)f | |||
| par-6 | PARD6 (PAR6) | PB1 domain | 3 / 3 | Pinheiro and Montell (2004)f |
| PatJ | INADL / MPDZ | L27 domain | 2 / 3 | Shin et al. (2007)f |
| Rim | RIMS2 | C2 domain | 2 / 3 | — |
| stardust | MPP5 (PALS1) | Guanylate kinase domain | 2 / 3 | — |
| L27 domain | ||||
| Src homology 3 domain | ||||
| veli | LIN7A / LIN7B / LIN7C | L27 domain | 2 / 2 | — |
a
Putative homologs were found using NCBI Homologene and UniProt.
b
Protein domains were identified using NCBI Conserved Domains Database and Interpro.
c
Number of RNAi lines that resulted in a migration defect out of all lines tested.
d
Cited references describe the Drosophila gene or its homologs.
e
Pertains to studies in Drosophila.
f
Pertains to the mammalian homolog.