Table 1.
Composition of prepared powders containing fenofibrate and Neusilin® UFL2 in different ratios
| Formulation |
Experimental parameter
|
Ratio of ingredients (%)
|
||
|---|---|---|---|---|
| Temperature (K) | Pressure (MPa) | Fenofibrate | Neusilin UFL2 | |
| Supercritical method | ||||
| SC1 | 323.15 | 9 | 67 | 33 |
| SC2 | 323.15 | 9 | 50 | 50 |
| SC3 | 323.15 | 9 | 40 | 60 |
| SC4 | 323.15 | 9 | 33 | 67 |
| Solvent evaporation method | – | – | 40 | 60 |
| Hot-melt adsorption method | – | – | 40 | 60 |
Abbreviations: SC1, supercritical method 1 (fenofibrate:Neusilin UFL2 = 67:33); SC2, supercritical method 2 (fenofibrate:Neusilin UFL2 = 50:50); SC3, supercritical method 3 (fenofibrate:Neusilin UFL2 = 40:60); SC4, supercritical method 4 (fenofibrate:Neusilin UFL2 = 33:67).