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. 2012 Oct 25;7:5565–5575. doi: 10.2147/IJN.S36939

Table 3.

Physicochemical characterization of raw fenofibrate, Neusilin® UFL2, and the prepared powders

Formulation Total pore volume (cm3/g) Specific surface area (m2/g) AC (%)
Fenofibrate raw material 100
Neusilin UFL2 raw material 1.476 403.93
SC1 0.190 31.35 32.16 ± 3.91
SC2 0.397 60.95 1.83 ± 0.35
SC3 0.486 72.11 0.00
SC4 0.668 110.75 0.00
Solvent evaporation method 0.521 81.91 4.21 ± 1.09
Hot-melt adsorption method 0.589 92.54 9.43 ± 2.11

Notes: AC, AC (%) = Csample/Craw × 100 where AC is the amount of crystalline drug in the sample, Csample is the area under the fenofibrate melting peak for the sample, and Craw is the area under the melting peak for the raw fenofibrate.

Abbreviations: SC1, supercritical method 1 (Fenofibrate:Neusilin UFL2 = 67:33); SC2, supercritical method 2 (Fenofibrate:Neusilin UFL2=50:50); SC3, supercritical method 3 (Fenofibrate:Neusilin UFL2 = 40:60); SC4, supercritical method 4 (Fenofibrate:Neusilin UFL2 = 33:67).