Table 3.
Physicochemical characterization of raw fenofibrate, Neusilin® UFL2, and the prepared powders
| Formulation | Total pore volume (cm3/g) | Specific surface area (m2/g) | AC (%) |
|---|---|---|---|
| Fenofibrate raw material | – | – | 100 |
| Neusilin UFL2 raw material | 1.476 | 403.93 | – |
| SC1 | 0.190 | 31.35 | 32.16 ± 3.91 |
| SC2 | 0.397 | 60.95 | 1.83 ± 0.35 |
| SC3 | 0.486 | 72.11 | 0.00 |
| SC4 | 0.668 | 110.75 | 0.00 |
| Solvent evaporation method | 0.521 | 81.91 | 4.21 ± 1.09 |
| Hot-melt adsorption method | 0.589 | 92.54 | 9.43 ± 2.11 |
Notes: AC, AC (%) = Csample/Craw × 100 where AC is the amount of crystalline drug in the sample, Csample is the area under the fenofibrate melting peak for the sample, and Craw is the area under the melting peak for the raw fenofibrate.
Abbreviations: SC1, supercritical method 1 (Fenofibrate:Neusilin UFL2 = 67:33); SC2, supercritical method 2 (Fenofibrate:Neusilin UFL2=50:50); SC3, supercritical method 3 (Fenofibrate:Neusilin UFL2 = 40:60); SC4, supercritical method 4 (Fenofibrate:Neusilin UFL2 = 33:67).