Table 4.
Dissolution efficiency at 60 minutes, percentage of drug dissolved at 10 and 30 minutes, and the relative dissolution rate from raw fenofibrate, the commercial product, and powders prepared using various adsorption methods
| Formulations |
% drug dissolved
|
DE (60 minutes) | RDR (10 minutes) | |
|---|---|---|---|---|
| 10 minutes | 30 minutes | |||
| Unprocessed drug | 16.45 ± 1.43 | 53.78 ± 1.35 | 48.87 ± 1.52 | 1 |
| Commercial product | 38.72 ± 6.57 | 91.91 ± 4.89 | 73.90 ± 5.19 | 2.35 |
| Processed drug | ||||
| SC3 | 94.29 ± 1.78 | 99.40 ± 2.56 | 92.28 ± 1.49 | 5.73 |
| Solvent evaporation method | 82.04 ± 1.22 | 93.98 ± 2.87 | 86.54 ± 0.98 | 4.98 |
| Hot-melt adsorption method | 77.96 ± 1.38 | 92.18 ± 2.98 | 84.63 ± 1.11 | 4.73 |
Note: Data are expressed as the mean ± standard deviation (n = 6).
Abbreviations: DE, calculated from the area under the dissolution curve at 60 minutes and expressed as percentage of the area of the rectangle described by 100% dissolution in the same time; RDR, ratio between amount of drug dissolved from each formulation and that dissolved from unprocessed drug at 10 minutes; SC3, supercritical method 3 (fenofibrate:Neusilin UFL2 = 40:60).