Table 3.
Diagnostic performance of other biomarkers for neonatal sepsis
| Biomarker name | Sample size (n) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Cut-off | LOD | ROC (AUC) | Assay method | Reference |
|---|---|---|---|---|---|---|---|---|---|---|
|
Soluble intercellular adhesion molecule 1 (sICAM-1) |
149 |
77 |
76 |
67 |
84 |
228 ng/mL |
0.096 ng/mL |
0.79 |
ELISA |
51 |
| 43 |
88 |
86 |
75 |
94 |
300 ng/mL |
Not given |
Not given |
Not given |
56 |
|
| Apolipoprotein C2 (ApoC2) | 80 | Not evaluated | Not given | 0.3 ng/mL | 0.79 | Mass spectrometry and ELISA | 57 | |||
PPV – positive predictive value, NPV – negative predictive value, ROC (AUC) – receiver operator curve (area under the curve), LOD – lower limit of detection, ELISA – enzyme-linked immunosorbent assay