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A single dose of ZA/CG gel has limited activity against vaginal SHIV-RT infection. (A) ZA/CG or CG gel was applied either 24 h before, 8 h before, or 1 h after vaginal SHIV-RT challenge. The number of animals in each treatment group is indicated. For CG gel this includes 9 real time and 16 historical controls. Plasma viral loads for each animal are shown over time (SIV RNA copies/ml of plasma. (B) Mean (±SEM) plasma viral load of infected animals from each group.
