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Two protein complexes constitute the main mechanical link between the actin cytoskeleton and the ECM. Owing to their pivotal role in muscle integrity, deficiencies in components of the integrin-associated complex (left) or the dystrophin-associated glycoprotein complex (DGC; right) can result in MDs. DAG, dystroglycan; DMD, dystrophin; DTN, dystrobrevin; ILK, integrin-linked kinase; NOS, nitric oxide synthase; SG, sarcoglycan; SNT, syntrophin; SSPN, sarcospan.
