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Processing of APP. In the non-amyloidogenic pathway of APP processing, APP is proteolytically cleaved within the Aβ region (red box) by α-secretase (α). In the amyloidogenic pathway, APP is cleaved first by β-secretase (β) and subsequently by γ-secretase (γ) to generate the pathological Aβ fragments that accumulate in brains of individuals with AD.
