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. 2012 Jun 26;5(6):812–822. doi: 10.1242/dmm.009910

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 6. — Hmx1 is expressed in CM of neural crest and non-crest origin. A Wnt1-Cre transgenic line was interbred with the reporter strain Ai6, expressing the fluorescent protein ZEG from a modified Rosa26 locus. Mouse embryos were analyzed at E12.5. (A) Whole-mount E12.5 embryo showing planes of section for levels analyzed in subsequent views. The ganglia and projections of the sensory peripheral nervous system are marked by expression of a LacZ transgene targeted to the Brn3a locus. (B–F) Progressively more ventral and caudal sections showing expression of Hmx1 in crest-derived and mesoderm-derived CM. The endogenous fluorescence of the ZEG reporter appears in green. Dashed lines demarcate the border of the cranial neural-crest-derived tissue. BA1-4, branchial arch 1–4; Di, diencephalon; GG, geniculate ganglion; Hb, hindbrain; inf IX/X, inferior part of IX–X ganglion complex (nodose and petrosal ganglia); mnTG, mandibular lobe, trigeminal ganglion; mxTG, maxillary lobe, trigeminal ganglion; Ret, retina; SAG, statoacoustic ganglion; SG, superior ganglion (of the IX–X ganglion complex).