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. 2012 May 31;5(6):823–833. doi: 10.1242/dmm.008557

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© 2012. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 6. — Haemin-induced neuronal death is IL-1 dependent in OSCs. Treatment of OSCs with haemin (30 μM; oxidation product of haem) induced neuronal death, as seen by PI staining, mainly in the dentate gyrus (DG) and CA1 regions of the hippocampus (A). This effect was abolished by co-treatment with IL-1Ra (500 ng/ml). (B) Representative images of PI staining in OSCs after treatment (note that the image intensity of the haemin + IL-1Ra example has been increased in order to visualise the hippocampus). Haemin treatment induced the expression of IL-1α (C) and IL-1β (D), measured by ELISA, with IL-1α being the predominant isoform induced (n=3–5, P=0.0037 between IL-1α and IL-1β after 6 hours). *P<0.05, **P<0.01, ***P<0.001.