Table 2.
Association of age, sex, education and APOE with cognitive decline
| Model A | Model B | |||
|---|---|---|---|---|
| Effect | EST (SD) | 95% CI | EST (SD) | 95% CI |
| Intercept | −0.076 (0.034) | −0.142, −0.009 | 0.134 (0.025) | 0.085, 0.182 |
| Age* | −0.019 (0.004) | −0.027, −0.011 | −0.011 (0.003) | −0.017, −0.006 |
| Sex (male) | −0.147 (0.057) | −0.261, −0.037 | −0.069 (0.042) | −0.152, 0.013 |
| Education (years) | 0.042 (0.007) | 0.028, 0.056 | 0.043 (0.005) | 0.033, 0.053 |
| APOE | −0.102 (0.054) | −0.208, 0.005 | 0.029 (0.042) | −0.055, 0.112 |
| Slope_before | −0.090 (0.008) | −0.106, −0.074 | −0.051 (0.007) | −0.063, −0.037 |
| Age × Slope_before | −0.001 (0.001) | −0.003, 0.0008 | −0.001 (0.0007) | −0.003, −2.8E−6 |
| Sex × Slope_before | 0.006 (0.014) | −0.020, 0.032 | 0.012 (0.010) | −0.007, 0.033 |
| Education (years) × Slope_before | 0.0003 (0.002) | −0.003, 0.004 | −0.002 (0.001) | −0.004, 0.001 |
| APOE × Slope_before | −0.033 (0.013) | −0.058, −0.008 | −0.024 (0.010) | −0.043, −0.003 |
| Slope_after | −0.337 (0.023) | −0.383, −0.293 | −0.273 (0.021) | −0.314, −0.233 |
| Age × Slope_after | −0.003 (0.003) | −0.008, 0.002 | −0.006 (0.026) | −0.011, −0.001 |
| Sex × Slope_after | 0.034 (0.038) | −0.041, 0.110 | 0.070 (0.035) | 0.0004, 0.137 |
| Education (years) × Slope_after | −0.012 (0.005) | −0.021, −0.003 | −0.011 (0.004) | −0.020, −0.003 |
| APOE × Slope_after | −0.093 (0.036) | −0.164, −0.025 | −0.103 (0.036) | −0.172, −0.033 |
| Change point | 5.688(0.234) | 5.228, 6.142 | 5.554 (0.228) | 5.107, 6.002 |
| Age × Change point | −0.138 (0.026) | −0.188, −0.088 | −0.137 (0.028) | −0.190, −0.083 |
| Sex × Change point | −0.608 (0.358) | −1.297, 0.084 | −0.699 (0.363) | −1.396, 0.018 |
| Education (years) × Change point | 0.155 (0.045) | 0.066, 0.244 | 0.181 (0.044) | 0.095, 0.268 |
| APOE × Change point | −0.519 (0.337) | −1.172, 0.150 | −0.386 (0.361) | −1.091, 0.317 |
| SD of random effect | ||||
| Random intercept | 0.435 (0.129) | 0.399, 0.474 | 0.324 (0.098) | 0.296, 0.354 |
| Random slope_before | 0.074 (0.028) | 0.064, 0.085 | 0.056 (0.021) | 0.048, 0.063 |
| Random slope_after | 0.247 (0.092) | 0.215, 0.281 | 0.247 (0.091) | 0.216, 0.281 |
| Random change point | 2.218 (0.716) | 1.993, 2.448 | 2.203 (0.726) | 1.974, 2.442 |
CI: Credible interval; Age: age at enrollment centered at 79; Education (years): years of education centered at 16; APOE: 1 for carriers of ε4 allele, 0 for noncarriers; Slope_before: slope estimate before the change point; Slope_after: slope estimate after the change point;