Table 1. Down- and upregulated miRNAs in osteosarcoma cell lines versus bone.
| miRNA | miR family | miR cluster | Fold change | Presence CL/Bone |
| Downregulated | ||||
| miR-451 | miR-451/miR-144 | −28000 | 1/4 | |
| miR-1 | miR-1/206 | miR-1/miR-133a | −550 | 4/All |
| miR-144/miR-144* | miR-451/miR-144 | −280/−87 | 0/3 | |
| miR-223 | −240 | 0/All | ||
| miR-142-3p | −190 | 7/4 | ||
| miR-133b | miR-133 | miR-206/miR-133b | −86 | 4/All |
| miR-150 | −84 | 0/4 | ||
| miR-206 | miR-1/206 | miR-206/miR-133b | −81 | 0/All |
| miR-126/126* | −65/−30 | 17/4 (1/4) | ||
| miR-486-5p | −42 | 5/4 | ||
| miR-195 | miR-15/16/195/424/497 | miR-195/miR-497 | −24 | All |
| miR-497 | miR-15/16/195/424/497 | miR-195/miR-497 | −22 | 12/4 |
| miR-363 | miR-25/32/92/92ab/363/367 | −14 | 6/All | |
| miR-133a | miR-133 | miR-1/miR-133a | −9.2 | 3/4 |
| Upregulated | ||||
| miR-18a | miR-18 | miR-17-92 | 95 | All/2 |
| miR-9/miR-9* | 65/42 | 18/0 | ||
| miR-301a | miR-130/301 | 47 | All/2 | |
| miR-18b | miR-18 | miR-106a-92 | 47 | All/1 |
| miR-31/miR-31* | 35 | 14/1 (14/0) | ||
| miR-503 | 27 | 18/0 | ||
| miR-301b | miR-130/301 | miR-301b/130b | 23 | All/0 |
| miR-21* | 22 | 18/1 | ||
| miR-7 | 21 | 18/1 | ||
| miR-137 | 19 | 10/0 | ||
| miR-96 | miR-96/miR-182 | 18 | All/2 | |
| miR-130b | miR-130/301 | miR-301b/130b | 14 | All/1 |
| miR-19a | miR-19 | miR-17-92a | 13 | All |
| miR-196a | miR-196 | 10 | All/2 | |
| miR-542-3p | miR-542/miR-450a | 8.3 | All/2 | |
| miR-29b | miR-29 | miR-29b-2/miR-29c | 7.1 | All |
| miR-106a | miR-17-5p/20/93/106/519 | miR-106a-92 | 7.1 | All/2 |
| miR-32 | miR-25/32/92/92ab/363/367 | 6.5 | All/1 | |
| miR-421 | miR-421/374b | 6.1 | All/1 | |
| miR-17 | miR-17-5p/20/93/106/519 | miR-17-92a | 5.8 | All |
| miR-99b | miR-99b/let7/miR-125a | 5.7 | All | |
| miR-20a | miR-17-5p/20/93/106/519 | miR-17-92a | 5.5 | All |
| miR-125a-5p | miR-99b/let7/miR-125a | 5.3 | All | |
| miR-93 | miR-17-5p/20/93/106/519 | miR-106b-25 | 4.9 | All |
| miR-19b | miR-19 | miR-17-92/miR-106a-92 | 4.8 | All |
| miR-106b | miR-17-5p/20/93/106/519 | miR-106b-25 | 4.5 | All |
| miR-182 | miR-96/miR-182 | 4.5 | 12/0 | |
| miR-450a | miR-542/miR-450a | 4.4 | All/1 | |
| miR-20b | miR-17-5p/20/93/106/519 | miR-106a-92 | 4.3 | All |
| miR-196b | miR-196 | 4.3 | All | |
| miR-374a | miR-374 | 4.0 | All | |
| let-7e | miR-99b/let7/miR-125a | 3.8 | All | |
| miR-181b | miR-181 | 3.6 | All | |
| miR-374b | miR-374 | miR-421/374b | 3.3 | All |
| miR-103 | miR-103/107 | 2.9 | All | |
| miR-181d | miR-181 | 2.7 | All/3 | |
| miR-29a | miR-29 | miR-29a/miR-29b-1 | 2.5 | All |
| miR-25 | miR-25/32/92/92ab/363/367 | miR-106b-25 | 2.4 | All |
| miR-92a | miR-25/32/92/92ab/363/367 | miR-17-92/miR-106a-92 | 2.3 | All |
| miR-107 | miR-103/107 | 2.1 | All |
The table lists 43 conserved miRNAs that are transcribed together from polycistronic miRNA clusters and/or belong to the same conserved families. In addition the top10 miRNAs are included (bold), of which some belong to the common families or clusters. miRNAs with common features are annotated with miRNA family and/or cluster members. For miRNAs detected as present in only a minority of the samples, the fold change (mean of cell lines vs bone) could be overestimated. Cell lines (CL), n = 19; bone, n = 4.