Table 7. Percentage of in-trial allocation for the partial order continual reassessment method for eight possible orderings.
Scenario | Dose | d1 | d2 | d3 | d4 | d5 | d6 | d7 | d8 |
---|---|---|---|---|---|---|---|---|---|
1 | R(di) | 0.09 | 0.20 | 0.26 | 0.44 | 0.58 | 0.74 | 0.83 | 0.90 |
POCRML | 0.25 | 0.31 | 0.28 | 0.07 | 0.06 | 0.01 | 0.01 | 0.00 | |
POCRM | 0.15 | 0.30 | 0.30 | 0.14 | 0.11 | 0.00 | 0.00 | 0.00 | |
2 | R(di) | 0.05 | 0.10 | 0.20 | 0.30 | 0.45 | 0.58 | 0.70 | 0.81 |
POCRML | 0.10 | 0.27 | 0.28 | 0.16 | 0.14 | 0.02 | 0.02 | 0.00 | |
POCRM | 0.03 | 0.23 | 0.27 | 0.27 | 0.19 | 0.01 | 0.01 | 0.00 | |
3 | R(di) | 0.06 | 0.12 | 0.22 | 0.30 | 0.45 | 0.55 | 0.70 | 0.84 |
POCRML | 0.11 | 0.27 | 0.27 | 0.16 | 0.14 | 0.02 | 0.02 | 0.00 | |
POCRM | 0.05 | 0.23 | 0.25 | 0.26 | 0.19 | 0.01 | 0.01 | 0.00 | |
4 | R(di) | 0.02 | 0.05 | 0.11 | 0.20 | 0.35 | 0.58 | 0.70 | 0.81 |
POCRML | 0.03 | 0.17 | 0.22 | 0.27 | 0.23 | 0.04 | 0.03 | 0.00 | |
POCRM | 0.01 | 0.13 | 0.15 | 0.39 | 0.29 | 0.02 | 0.01 | 0.00 | |
5 | R(di) | 0.01 | 0.04 | 0.07 | 0.10 | 0.20 | 0.35 | 0.50 | 0.64 |
POCRML | 0.02 | 0.10 | 0.12 | 0.25 | 0.26 | 0.14 | 0.10 | 0.02 | |
POCRM | 0.00 | 0.04 | 0.05 | 0.35 | 0.38 | 0.11 | 0.06 | 0.00 | |
6 | R(di) | 0.01 | 0.02 | 0.05 | 0.09 | 0.15 | 0.20 | 0.40 | 0.52 |
POCRML | 0.01 | 0.08 | 0.08 | 0.20 | 0.20 | 0.21 | 0.15 | 0.06 | |
POCRM | 0.00 | 0.01 | 0.01 | 0.24 | 0.31 | 0.32 | 0.11 | 0.00 | |
7 | R(di) | 0.01 | 0.03 | 0.05 | 0.08 | 0.10 | 0.22 | 0.41 | 0.55 |
POCRML | 0.01 | 0.07 | 0.08 | 0.19 | 0.19 | 0.24 | 0.16 | 0.06 | |
POCRM | 0.00 | 0.02 | 0.03 | 0.29 | 0.32 | 0.22 | 0.13 | 0.00 | |
8 | R(di) | 0.01 | 0.02 | 0.04 | 0.06 | 0.08 | 0.10 | 0.20 | 0.35 |
POCRML | 0.01 | 0.07 | 0.07 | 0.12 | 0.11 | 0.21 | 0.21 | 0.21 | |
POCRM | 0.00 | 0.01 | 0.01 | 0.20 | 0.22 | 0.29 | 0.26 | 0.00 |
The target MTD combinations are in boldface.