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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Gastroenterology. 2012 May 17;143(3):821–31.e1-2. doi: 10.1053/j.gastro.2012.05.009

Figure 4. Increased apoptosis and decreased cell proliferation in Bmi1 KO pancreas after caerulein pancreatitis.

Figure 4

(A) Co-staining for cleaved Caspase 3 (c-Caspase 3)/E-cadherin/DAPI in control and Bmi1 KO pancreata 3 days post caerulein injection.

(B) Co-staining for TUNEL/E-cadherin/DAPI in contro l and Bmi1 KO pancreata 3 days post caerulein injection.

(C) Quantification of the number of Cleaved Caspase 3/E-cadherin double positive cells per field in control and Bmi1 KO pancreata 3 days and 7 days post-injection. N = 3 mice.

(D) Co-staining for phospho-histone H3 (PHH3)/E-cadherin/DAPI in control and Bmi1 KO pancreata 3 days post caerulein injection.

(E) Quantification of the number of PHH3/E-cadherin double positive cells per field in control and Bmi1 KO pancreata 3 days and 7 days post caerulein injection. N = 3 mice. Means ± SD. ** p < 0.01.