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. Author manuscript; available in PMC: 2013 Sep 1.
Published in final edited form as: Gastroenterology. 2012 May 17;143(3):821–31.e1-2. doi: 10.1053/j.gastro.2012.05.009

Figure 5. p16, p19 and p53 apoptotic pathways are upregulated in Bmi1 KO pancreata after caerulein injury.

Figure 5

(A) Relative expression levels of Cdkn2a, p16 and p19 in the pancreas by q-PCR analyses. N = 3 mice. Means ± SD

(B) Co-staining for p16/Sox9 in control and Bmi1 KO pancreata 3 days post-injection. The merged image shows increased p16 expression in Sox9-positive duct-like epithelial cells in Bmi1 KO mice 3 days post caerulein injection.

(C) Co-staining for phospho-Rb/DAPI in control and Bmi1 KO pancreata 3 days post caerulein injection.

(D) Immunohistochemistry for p53 in control and Bmi1 KO pancreata 3 days post caerulein injection.

(E) Relative expression levels of Noxa, Apaf1, Bax and p21 in the pancreas by q-PCR analyses. N = 3 mice. Means ± SD. * p < 0.05,** p < 0.01, and ***p< 0.001.