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. 2012 Oct 24;122(11):3990–4002. doi: 10.1172/JCI65508

Figure 3. Colocalization-FISH.

Figure 3

(A) Examples of colocalized vs. separate signal pairs in C28/I2 nuclei (distances in μm; scale bars: 2 μm). (B) Accumulated colocalized signals were found in all experiments. Shown are genomic distances between probes (in Mb); Mann-Whitney test was used to determine significance. PTHLH was in physical proximity to re18527 compared with the re18527 negative control, with a 9.5-Mb equidistant upstream probe 12p(1). (C) CISTR-ACT significantly showed interaction with PTHLH compared with the 3 controls. PTPLAD1 was not expressed in C28/I2. (D) re70373 was marginally in spatial proximity to SOX9. (E) Significant in trans actions of CISTR-ACT with SOX9. In the control of SOX9 with a chromosome 15q(1) probe, only 2 signal pairs had distances less than 1 μm.