Table 1.

Markers to identify colonic SCs and colon CSCs [13]

	Markers	Cellular Functions
Normal Stem Cell	Musahi-1	RNA binding protein
	Hes-1	Transcriptional repressor
	EphB receptors	Cell surface receptors
	Bmi-1	Policomb-repressor protein
	Lgr-5	Wnt target gene
	ALDH1A1	Enzyme
	DCAMKL1	Kinase
Colon Cancer Stem Cell	CD133	Associated with poor prognosis, low survival, and distant metastasis in colorectal adenocarcinoma.
	CD44	Hyaluronic acid receptor
	CD166	Call adhesion molecule
	ALDH1A1	Enzyme
	ATP binding cassette protein	Drug transporter, effluxes drugs.
	OCT4	POU-domain transcription factor, highly expressed in embryonic stem (ES) cells.
	SOX2	Group B of the Sox family of transcription factor, involved in development.
	c-Myc	Transcription factor, high c-Myc levels blocks cell differentiation and enhance self-renewal of committed and differentiated cells
	B-Integrin (CD29)	Cell adhesion molecule