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Quantitation of phenotypic abnormalities upon hos2 or HDAC3 over-expression from the nmt1 promoter in the absence of thiamine
| Morphological Abnormality | pREP1 | pREP1-hos2 | pREP1-HDAC3 |
|---|---|---|---|
| Normal |
> 99% |
52% |
54% |
| Rounded/Depolarized |
< 1% |
26.5% |
29% |
| Misplaced septa |
<1% |
9% |
5% |
| Excessive/Misplaced septal deposits |
0 |
6% |
6% |
| Multiple septa |
0 |
2% |
2% |
| Elongated with multiple aberrant deposits of septal material |
0 |
3% |
2% |
| Elongated and Branched | 0 | 1.5% | 1.5% |
