Table 1.

Ranges considered for six classes of model parameters

Parameter class	Estimated range	Units
Rate constant for a bimolecular association reaction	10-7 – 10-5	(molecules/cell)-1·s-1
Rate constant for a unimolecular dissociation reaction	10-2 – 100	s-1
Rate constant for a phosphatase-catalyzed reaction*	10-3 – 10-1	s-1
Rate constant for a receptor trafficking step (internalization or recycling)*	10-3 – 10-1	s-1
Rate constant for endocytic degradation*	10-3 – 10-1	s-1
Protein copy number	104 – 106	molecules/cell

Processes characterized by parameter classes marked by asterisks are taken to be first-order processes.