Table 6.
SBRT of adrenal gland metastases
| Patients (N) | Median dose (Gy) | Median follow up (mos) | Outcomes | |
|---|---|---|---|---|
| Chawla et al., 2009 [62] |
30 |
40 Gy (16–50)/4–10 fractions |
9.8 |
At 1-year: survival: 44%, LC: 55%, distant control rate, 13% |
| |
|
|
|
No late Grade ≥2 toxicity |
| Holy et al., 2011[63] |
18 |
20-40 Gy/5 fractions |
21 |
In 13 patients with isolated adrenal metastasis: LC :77%, OS:23 months |
| Casamassima et al., 2012 [64] |
48 |
36 Gy/3 fractionsa |
16.2 |
At 1 and 2 years, LC: 90%; OS: 39.7% and 14.5%, resp. |
| |
|
|
|
1 case of Grade 2 adrenal insufficiency |
| Scorsetti et al., 2012 [65] |
34 |
32 Gy/4 fractions |
41 |
At 1 and 2 years: LC 66% and 32%, resp. |
| No significant acute and late toxicities |
a70% isodose, 17.14 Gy per fraction at the isocenter. Eight patients were treated with single-fraction (23 Gy) stereotactic radiosurgery.