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. 2012 Oct 8;6:342. doi: 10.1186/1752-1947-6-342

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Copyright ©2012 Michelan et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(A) Paracoccidioides brasiliensis with multiple peripheral buds in the typical ‘pilot wheel’ configuration (arrow) (periodic acid-Schiff stain, 400×); (B) Birefringent rings, some of which show lateral budding cells being phagocytosed by multinucleated foreign-body giant cells (open arrow) (hematoxylin and eosin stain, 400×); and (C) the chronic granulomatous inflammatory process characterized by epithelioid cells and multinucleated giant cells surrounding the fungi (hematoxylin and eosin stain, 100×).