Table 1.
Anti-pseudomonal agents in vitro activity against P. aeruginosa (n = 64) in planktonic and in biofilm conditions
|
Antimicrobial Agent |
Range MIC/ BIC |
No. of isolates inhibited by different MIC/BIC values (mg/L) (n=64) |
MIC50/ BIC50(mg/L) |
MIC90/ BIC90(mg/L) |
Pvalue |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | ≥256 | |||||
|
CAZ |
0.5-256/ 0.5-256 |
3/5 |
16/10 |
22/11 |
8/1 |
6/3 |
3/6 |
2/4 |
3/4 |
0/4 |
1/12 |
2/8 |
16/256 |
<0.001 |
|
CIP |
0.5-128/ 0.5-256 |
42/31 |
3/10 |
7/4 |
2/2 |
1/3 |
5/3 |
3/4 |
0/4 |
1/1 |
0/2 |
0.5/1 |
16/64 |
0.016 |
|
TOB |
0.5-256/ 0.5-256 |
9/4 |
17/6 |
18/13 |
7/11 |
1/7 |
1/10 |
1/4 |
3/4 |
0/1 |
7/4 |
2/4 |
64/64 |
0.008 |
|
IPM |
0.5-128/ 0.5-256 |
21/8 |
17/1 |
6/2 |
5/9 |
7/6 |
6/11 |
1/6 |
0/5 |
1/5 |
0/11 |
1/16 |
16/256 |
<0.001 |
| MEM | 0.5-64/ 0.5-256 | 38/21 | 7/0 | 7/18 | 6/7 | 4/10 | 0/0 | 1/2 | 1/0 | 0/1 | 0/5 | 0.5/2 | 4/32 | <0.001 |
Detailed legend: CAZ - ceftazidime, CIP - ciprofloxacin, TOB - tobramycin, IPM - imipenem, MEM - meropenem, P – statistical significance (< 0.05), MIC – minimal inhibitory concentration, BIC – biofilm inhibitory concentration.