Table 1.
Integration frequency of HIV in RefSeq genes
| Cell line | # sites | % in RefSeq genes | |
|---|---|---|---|
|
HIV-fLuc |
WT |
1468 |
77.5 ***|ns|*** |
|
sites |
HRP-2 KD |
359 |
80.2 ***|ns|*** |
| |
LEDGF/p75 KD |
477 |
67.7 ***|***|ns |
| |
LEDGF/p75 KD HRP-2 KD |
676 |
53.7 ***|***|*** |
| |
LEDGF/p75 KD + HRP-2 |
445 |
77.5 ***|ns|*** |
|
MRC sites |
WT |
4404 |
39.7 |
|
(HIV-fLuc) |
HRP-2 KD |
1077 |
37.9 |
| |
LEDGF/p75 KD |
1431 |
40.3 |
| |
LEDGF/p75 KD HRP-2 KD |
2028 |
39.3 |
| LEDGF/p75 KD + HRP-2 | 1335 | 40.2 |
Abbreviations: MRC matched random control, ns non-significant (p ≥ 0.05). Asterisks represent p-values (*p < 0.05, **p < 0.01, ***p < 0.001) given after comparison with MRC|WT|LEDGF/p75 KD respectively. Significance was determined using a two-tailed Chi-square test. P-values were not corrected for multiple comparisons; alpha level is 0.003 after Bonferroni-correction (0.05/15).