Table 2. Allele frequencies of the gene polymorphisms in 365 patients treated with chemotherapy.
Gene | Mutation | Wild-type(N/%) | Heterozygous(N/%) | Homozygous(N/%) |
ERCC5 | D1104H, C/G | 102(27.7) | 181(49.2) | 82(22.3) |
ERCC6 | M1097V,A/G | 329(90.1) | 27(7.1) | 7(2.5) |
Q1413R,A/G | 330(90.4) | 35(9.6) | 0 | |
R1213G, A/G | 330(90.4) | 35(9.6) | 0 | |
CCNH | V270A, T/C | 307(84.1) | 54(14.8) | 4(1.1) |
MMS19L | G811A, G/A | 114(31.2) | 182(49.9) | 69(18.9) |
XPC | Q940K, A/C | 145(39.7) | 173(47.4) | 47(12.8) |
R500W, C/T | 151(41.4) | 157(43) | 56(15.3) | |
RRM1 | C37A, C/A | 169(46.3) | 170(46.6) | 26(7.1) |
N = Number of patients.