Figure 3. Diagrammatically showing the favorable conformation obtained by docking Ly465608 and Cpd#1 into (A) PPARα, (B) PPARβ and (C) PPARγ, respectively.

The binding pocket in the current study is defined by those residues with its heavy atoms within a distance limitation of 5 Å from LY465608 or Cpd#1. The AF2 function domain is shown in red helix, and the hydrophobic surfaces of the ligand-binding domain are colored in green. The dotted lines show the hydrogen bonding interactions between the receptors and ligands.