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. 2012 Oct 31;7(10):e48461. doi: 10.1371/journal.pone.0048461

Figure 1. Actions of FXR ligands on proliferation of human colon cancer cells.

Figure 1

Dose-response for FXR antagonist guggulsterone-induced proliferation of H508 cells (A), SNU-C4 cells (B) and HT-29 cells (C). Dose-response for FXR agonist GW4064-induced inhibition of proliferation of H508 cells (D), SNU-C4 cells (E) and HT-29 Cells (F). Cells were incubated for 2–5 days at 37°C with FXR ligands at the indicated concentrations. Cell proliferation was measured as described in Materials and Methods. Values represent mean ± SE from at least 3 separate experiments; *p<0.05 vs. control (Student’s t-test).