Table 2. Enhancement features of the gallbladder diseases on contrast-enhanced ultrasound.
| Enhancement features | Malignant (n = 51) | Benign (n = 141) | P * | |||||
| Cholesterol polyp (n = 63) | Adenoma (n = 21) | Adenomyomatosis (n = 14) | Chronic cholecystitis (n = 31) | Biliary sludge (n = 12) | Total# (n = 141) | |||
| Enhancement time | ||||||||
| Arrival time (sec) | 15.5(3.4) | 15.6(3.8) | 13.6(3.8) | 13.6(3.6) | 16.9(4.2) | NA | 15.3(4.0) | 0.509 |
| range (min - max) | (9–24) | (9–27) | (7–20) | (7–22) | (10–27) | (7–27) | ||
| Time to peak (sec) | 20.3(4.4) | 18.9(3.8) | 18.0(4.3) | 18.0(3.7) | 20.8(4.0) | NA | 19.0(4.0) | 0.028 |
| range (min - max) | (10–32) | (13–30) | (11–27) | (13–27) | (14–30) | (11–30) | ||
| Washout time (sec) | 41.4(19.4) | 47.7(24.2) | 87.3(34.7) | 53.1(25.5) | 62.4(36.1) | NA | 58.2(32.2) | <0.001 |
| range (min - max) | (15–120) | (18–120) | (27–170) | (26–120) | (25–176) | (18–176) | ||
| Intralesional vessels | ||||||||
| Branched | 6 (11.8%) | 0 | 0 | 0 | 0 | NA | 0 | <0.001 |
| Linear | 44 (86.3%) | 10(15.9%) | 17(81.0%) | 9(64.3%) | 15(48.4%) | NA | 51 (39.5%) | |
| Dotted | 1(1.9%) | 53(84.1%) | 4(19.0%) | 5(35.7%) | 16(51.6%) | NA | 78 (60.5%) | |
| Enhancement pattern | ||||||||
| Homogeneous | 16 (31.4%) | 63(100%) | 21(100%) | 9(64.3%) | 17(54.8%) | NA | 110 (85.3%) | <0.001 |
| Inhomogeneous | 35(68.6%) | 0 | 0 | 5(35.7%) | 14(45.2%) | NA | 19 (14.7%) | |
| Enhancement extent | ||||||||
| Arterial phase | ||||||||
| Hyper- | 45(88.2%) | 50(79.4%) | 20(95.2%) | 13(92.9%) | 28(90.3%) | NA | 111(86.0%) | 0.008 |
| Iso- | 3(5.9%) | 13(20.6%) | 1(4.8%) | 1(7.1%) | 3(9.7%) | NA | 18(14.0%) | |
| Hypo- | 3(5.9%) | 0 | 0 | 0 | 0 | NA | 0 | |
| Venous phase | ||||||||
| Hyper- | 0 | 0 | 0 | 0 | 0 | NA | 0 | 0.117 |
| Iso- | 0 | 2(3.2%) | 1(4.8%) | 1(7.1%) | 2(6.5%) | NA | 6 (4.7%) | |
| Hypo- | 51(100%) | 61(96.8%) | 20(95.2%) | 13(92.9%) | 29(93.5%) | NA | 123(95.3%) | |
| Wall intactness | ||||||||
| Intact | 11(21.6%) | 63(100%) | 21(100%) | 12(85.7%) | 24(77.4%) | 12(100%) | 132(93.6%) | <0.001 |
| Destructed | 40(78.4%) | 0 | 0 | 2(4.3%) | 7(22.6%) | 0 | 9(6.4%) | |
| Liver infiltration | ||||||||
| Present | 26(51.0%) | 0 | 0 | 0 | 1(3.2%) | 0 | 1(0.7%) | <0.001 |
| Absent | 25(49.0%) | 63(100%) | 21(100%) | 14(100%) | 30(96.8%) | 12(100%) | 140(99.3%) | |
*
Comparisons between malignant and benign gallbladder diseases. # n = 129 after excluding the 12 lesions of biliary sludge in the categories of intralesional vessel, enhancement pattern and enhancement extent. NA, not applicable.